Custom Enzymes and Inhibitors
Medchemexpress LLC NAE-IN-M22 100mg | 864420-54-2 | 363.32 g·mol^-1 | C20H24Cl2N2 | 100 MG
NAE-IN-M22 (CAS 864420-54-2) is a research-grade small molecule inhibitor of the NEDD8-activating enzyme (NAE). It is described as a potent, selective, and reversible inhibitor with micromolar cellular activity, suitable for biochemical and cell-based studies.
- Potent and selective NAE inhibitor.
- Reversible mechanism with micromolar activity in cell assays.
- Demonstrated induction of apoptosis in cancer cell lines, including A549.
- Available in solid form and as a 10 mM solution in DMSO for flexible use.
- High stated purity (~99.9%), appropriate for research applications.
Medchemexpress LLC Temsirolimus-Solid W/Slvnt | HY-50910-10MM SOLID/SLVNT
Temsirolimus-Solid W/Slvnt
Selleck Chemical LLC Temsirolimus (CCI-779) 50mg 162635-04-3 NSC 683864
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 ?M in a cell-free assay. Temsirolimus induces autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Ace Glass, Inc. 125mL GL25 top #25 bottom peptide vessel body, 2mm bore PTFE stopcock side port
125ML GL25 NO.25 PEPT BODY
Medchemexpress LLC NAE-IN-M22 25mg | 864420-54-2 | 363.32 g/mol | C20H24Cl2N2 | 25 MG
A potent, selective, reversible inhibitor of the NEDD8 activating enzyme (NAE) with demonstrated antiproliferative and proapoptotic activity in cancer cell lines and reported in vivo tumor growth inhibition. Supplied as a white to off-white solid with high purity and high solubility in DMSO, it is available in multiple pack sizes and solution formats for research use.
- Potent, selective, reversible NAE inhibition.
- Demonstrated antiproliferative and proapoptotic activity in cells.
- Effective in vivo tumor growth inhibition reported.
- High purity solid with white to off-white appearance.
- High solubility in DMSO and multiple stock concentration options.
Medchemexpress LLC Eprenetapopt Solid Plus Colven | HY-19726-100MN ML SOLID
Eprenetapopt Solid Plus Colven
Enzo Life Sciences Z-VAD(OMe)-FMK (1 mg) CAS: 187389-52-2
Caspase inhibitor. Irreversible and cell permeable broad-spectrum caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). For cell free assays use Prod. No. ALX-260-020. Alternative Name: Caspase family inhibitor (fluoromethylketone). Formula: C22H30N3O7F. MW: 467.5. CAS: 187389-52-2. Purity: ≥95%. Sequence Z-Val-Ala-Asp(OMe)-fluoromethylketone. Appearance: White to off-white solid. Solubility: Soluble in DMSO (>10mg/ml), dimethyl formamide (7mg/ml) or 100% ethanol (1.3mg/ml). Long Term Storage: -20°C. Use/Stability: Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be divided into aliquots and stored at -20°C for up to 1 month. Handling: Keep cool and dry.
Biotang Inc BIIB021, CNF2024, Free Base, > 99%, 25MG, M.W. 318.76, C14H15ClN6O, CAS#848695-25-0
BIIB021, CNF2024, Free Base, > 99%, 25MG, M.W. 318.76, C14H15ClN6O, CAS#848695-25-0
Ubpbio UB ALDEHYDE, 50UG
Ubiquitin Derivatives – Ubiquitin Aldehyde (UBPBio catalog# F3100) – Ub aldehyde is a potent and highly specific inhibitor of cysteine deubiquitinating enzymes including the Ub C-terminal hydrolases (UCHs), the Ub-specific proteases (USPs), the ovarian tumor domains (OTUs) proteases and the Machado-Josephine domain (MJD) proteases. Typical working concentration is 2-5 µM in vitro.
Selleck Chemical LLC Temsirolimus (CCI-779) 10mg 162635-04-3 NSC 683864
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 ?M in a cell-free assay. Temsirolimus induces autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Pazopanib HCl S1035-10mg
Pazopanib HCl is a novel multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM in cell-free assays respectively Pazopanib induces autophagic Type II cell death